The other thing to note is that recently published research has shown that when the various forms of B12 are imported into a cell, the first thing that happens is that the ligand (methyl, cyano, adenosyl or hydroxo) is removed from the cobalamin molecule, and then the two active forms, methylcobalamin and adenosylcobalamin are reformed in the approximate amounts needed by the cell.He did admit that the type of B12 one takes has some influence on the ratios of the different kinds of B12 in the cell. But I didn't notice that caveat the first time I read it. I stopped the adenosyl. I went back to hydroxo B12. In my sleep-deprived state, sleep became more important than anything and before experimenting, I had been sleeping about 8 hours every night.
Thanks Rich. We've all been hoping for more clarification on this as we plod along with OHB12 wondering if we should stick or switch. Clearly science is on the side of OH B-12 as both safe and effective.However, there is one piece of information in Freddd's posts you didn't address, but which I think is crucial. Freddd claims to have explored this protocol with some 600 people and found that 80% of them responded. It's not possible that he could have found such a high percentage of folks with CFS who share the same inherited mutation. Consequently, I think he has concluded that he is onto something that is not yet understood by science.I think we should beware of dismissing this experiential evidence if, indeed, he has guided nearly 600 people. For example, we've had scientists 'prove' that there is no possible difference between pharmaceutical grade ascorbic acid and natural Vit C, yet clinicians claimed better results with the natural, and now we're starting to understand that shape, charge, and energetic aspects of molecules add complexity to identical chemical formulas. We don't understand why homeopathy works -- and there are those who insist it doesn't work and can't work -- yet it seems to work in many people, including children and pets who have no placebo expectations.