Iodine levels also affect thyroid function and there is a relationship between the methylation cycle, sulfur groups and iodine levels. ... Lithium is concentrated in the thyroid and can inhibit iodine uptake. This is why it is important to monitor both the levels of iodine as well as lithium on essential mineral tests and supplement lithium only as needed for low values that may occur as a result of detoxification and excretion of mercury.When I saw lithium go way down on my hair analysis, and started having mood swings, I began to take a small amount of lithium (Li-zyme from Biotics Research). Today I sent in a urine test to monitor the levels, and will stop taking lithium until I get the test results. Iodine levels can be lowered by chelation.
Dr. Yasko wrote:
The thyroid hormone iodination cycle is tied to glucose 6 phosphate dehydrogenase levels. The use of supplements or chelating agents that deplete G6PDH levels can also affect thyroid hormone levels.
Sulfur based detox, like TD DMPS can have effects on G6PDH. Decreases in G6PDH can make the RBCs more fragile so they lyse more easily. Since RBCs "turnover" every 120 days, it is possible that the effects of sulfur based detox may not show up for several months.DMPS, DMSA, and all sulfur chelating agents can deplete G6PDH levels. I have been on DMPS, 0.5 mg I.V., and in Florida, took 3 DMSA capsules. Dr. Yasko explains the potentially harmful effects
Dr. Yasko wrote:
So it looks as if the increased cholesterol could also be due to the chelation with DMPS and/or the increased excretion of toxic metals (although I haven't tested fecal excretion).
As for low Vit D levels, I don't know a direct relationship, but there is an indirect relationship through the drop in G6PDH, the increase in blood sugar levels (yes, mine are higher than before), stress on the pancreas, and the need for Vit D.
According to Dr. Yasko I should increase liver and pancreas support. More supplements OMG!
Is there anything good? YES
Since I had a urine sample this morning, I decided to run a few home tests. I was very pleased to see that the MDA levels are improved. MDA is a measure of how much oxygen is damaging the fragile lipid membranes of cells. This is a process known as oxidative stress. It is a process that ages the body and which tends to be out-of-control high in CFS-ME. Mine previously tested in the severe range. Then I went down to very high. Now I am just at the borderline between low (which is the place to be!) and high. The normal levels of MDA correspond to the good results of other measures of oxidative stress in my recent Genova organic (metabolic) acids panel.
I discovered that taking a tiny bit of melatonin (1/3 of a 300 mg sublingual tablet) helps me fall asleep. In the past I could not tolerate it, which is why I didn't try it earlier. I am now waking only once during the night.
Some homocyst(e)ine showed up on my blood test. It was actually at a really good level (6.1), right near the middle of the reference range from 0- 15. This means that my methylation pathway is working again, for homocystine was 0 (ZERO) on the plasma amino acid test I took in late November. This is a good sign that things are turning around.
If I stop doing chelation, I will save money. And I won't have to drive as often on these snowy roads. The landscape is beautiful in the snow, quiet and still. I watch the finches landing on the feeder, their throats tinged with yellow, and remember that the days are already getting shorter. In less than three months, it will be Spring.