Monday, June 7, 2010

Coxsackie B: My Nemesis

I sat at the computer gaping with amazement.  Dr. Martin Lerner, who I’ve heard about at my Columbus Doc’s office as “the guy who focuses on viruses and antivirals”, has been researching cardiac issues in CFS since 1993.  He has done Holter tests and echocardiography and biopsies.  He has found that viral reactivation is the cause of relapses.  He has published his research in peer-reviewed scientific journals, working together with academic researchers at Wayne State University.   His work is thorough, detailed, and firmly rooted in science.  No muscle testing ‘proving’ to me that gliadin-rich wheat germ oil will help me.  I clicked on one link after another, voraciously reading until my eyes glazed over and my brain melted into a puddle. 


Thank you Peggy Munson for linking to his work in your blog!  It is wonderful how we all learn from one another.  Sharing information and our personal journeys not only lessens the bite of isolation, but brings us closer to solutions on our own healing journeys.

I made an appointment with a local cardiologist and, two days later, showed up with a bibliography of Lerner’s publications and an article describing his theories.  They glanced over it, copied it to put in my file, and explained to me the tests they would order:  a stress test (with exercise or a drug to dilate the arteries), an EKG, a 24 hour Holter or a week-long incident Holter, a sonogram of the heart.  “I’ve had all those tests before,” I said, “except the stress test, which I can’t do because the exercise will make my relapse worse.”

“We’ll do it with the drug then,” she said.  And I knew then that I would not waste another day in a doctor’s office.  At least not this doctor.  Lerner had found abnormalities in the T waves of CFS patients while they exercised, something that wouldn’t be found with a dilating drug.   Nor would I consider taking a beta-blocker to ease my chest pain when my blood pressure often dropped to 85/57.  I called Lerner’s office and made an appointment.

Although I had cancelled nearly all of my appointments with my Columbus NT doc, I hadn’t burned all of my bridges.  I went in at the end of the week and asked him to draw blood to retest my viral titers.  In the beginning of treatment, he had done the standard screening and found me to have evidence of past infection of EBV and HHV6, confirming what Dr. Sue Levine and others had found.  He also found me to have a slightly elevated titer for Coxsackie virus B 6, again indicating prior infection.  As in the past, I had concluded that viruses were not a big issue in my personal variation of ME-CFS.  But now I had the idea that, since I had never been tested during a relapse, I might show a very different picture.  I knew from personal experience that stress reactivates viruses in the herpes family.  I’d seen Dr. Ronald Glaser’s bibliography on the role of stress as a factor in reactivating the Epstein Barr Virus.  The reactivation of this virus would explain my symptoms.


Lo and behold, I did show viral reactivation of EBV and HHV6.  But the most significant elevation of viral titers was for Coxsackie B3, an enterovirus known for causing myocarditis.  I had found the cause of my relapses.

I've been researching the Coxsackie viruses.  They have been connected with ME-CFS by Dr. John Chia, who has found that 80% of his ME-CFS patients have either Coxsackie or Echo Virus upon biopsy of the stomach.  Coxsackie B Virus 3 (henceforth CBV3) is known to enter the body through the gut and then infect the heart and brain.  Like most other viruses, it only remains in the blood stream, detectable by PCR, for a few weeks.  Then it hides inside the cells of various body tissues.


The more I read about CBV3, the more it seemed to explain every single relapse I've had since my first recovery from ME-CFS in 1990.  Viruses are reactivated by stress, and all my relapses have been brought on by stress.  While the first one (1994) was characterized by digestive complaints and emotional turmoil from PTSD, the next two (2000 and 2007) started with cardiac hyperarousal which, after a few weeks, led to an aggravation of brain issues, orthostatic intolerance, digestive issues, endocrine issues, and fatigue.  Even when I felt great for a few weeks in the summer of 2007, before relapsing, I was getting frequent tachycardia, palpitations, and chest pain.  And my urinary amino acid testings showed evidence of malabsorption, while my stool testing showed a perfectly healthy mix of commensal bacteria and no pathogenic bowel organisms.


Viruses stay in the body forever, although they can be contained by a healthy immune system.  Normally, I would have seen this as cause for distress.  I would have cried and whined and begun to feel hopeless. But since getting several blessings from Mahendra Kumar Trivedi, I have believed that my body is capable of healing.  And Mr. Trivedi is a powerful ally on this path.

Trivedi is an Indian holy man who seems to have direct access to the Divine.  He shares his gifts by blessing the earth and blessing people.  His passion over the last few years has been to document scientifically the benefits of his blessings.  You can read more on the website of the 
TrivediFoundation, where you'll find data from research studies in agriculture, microbiology, physics, and genetics, as well as human wellness.  Of particular interest to me is Trivedi's work with viruses:  laboratories tested how he was able to reduce the levels of HIV, Hepatitis B and C, and Cytomegaloviruses in tubes of plasma.  At his introductory lecture, he presented a simple graph that made this research accessible to lay people.

Do you now understand why I felt optimistic?  If viral reactivation is causing my relapses, and if Mr. Trivedi can reduce my viral load, I can move to a state of increased wellness.  Even though I'll always have the virus in my system and therefore always have to be careful, if I get the virus into remission, I can rebuild my strength.  I can get stem cells to speed the rebuilding of damaged heart and brain cells.  And if I have a big stress and feel any cardiac symptoms, I can flood my bloodstream with herbal and pharmaceutical antivirals.  What a wonderful plan!



I didn't have long to wait to get started on the first step.  I signed up online for an individual remote blessing with Trivedi, and for a series of  two group blessings.  I also signed up to attend the retreat in Chicago because he was urging people with serious illnesses like MS and Parkinson's to attend.  I knew it would be a stretch for me to travel that far (7+ hours), stay in a hotel, and be present during the retreat, but I felt compelled to do it by a great inner force.  Fortunately, I had fantastic results, which is why I'm writing this evening after a full day of travel.  But, as it is now 10:30, I am going to retire for the night, and tell you all about my fantastic results in a few days.  I can barely wait to see how great I feel tomorrow!!


PS Sorry for the changing typefaces.  I can't seem to sort them out now.  :)

16 comments:

  1. Hi Janis
    I dont know whether you are aware, it seems that selenium protects the heart from CBV5 induced myocarditis, so it could well do the same for CBV3.

    http://www.ncbi.nlm.nih.gov/pubmed/11878751

    Heavy metals also appear to be implicated in CBV3 and the heart. As Se binds to heavy metals it could be that the heavy metals are lowering the protection given by Se against CBV3.

    I recently had my Se levels checked and despite taking 200mcg religously every day for the last 16 years, I still was only 50% of normal due to heavy metal toxicity, which just goes to show how heavy metals destroy our antioxidant protection.

    http://eurheartj.oxfordjournals.org/content/16/suppl_O/20.abstract

    ReplyDelete
    Replies
    1. Question for this poster or anyone reading in the future who may benefit)

      What kind of Selenium are you taking? There are different sources that are only absorbed 50% by the intestines. I found this interesting when I read your comment about only have '50% of the normal amount after taking it for 16 years'. Do a google search for the type you're taking and absorbing 50% and see what comes up.

      Here is an excerpt from Phoenix Rising forum on the subject of Selenium 'High Dose Selenium Improves My Energy and Brain Fog':
      "Other forms of selenium supplement include sodium selenate, and sodium selenite, but the absorption of these two forms in the gut is only around 50%, whereas the absorption of selenomethionine in the gut is near 100%. If you take the less absorbable forms of selenium, you may have to increase your dose to compensate for the poorer assimilation.

      • Selenomethionine comes in both a yeast-free form, and a yeast-derived form. I would avoid the yeast-derived form of selenomethionine, because I found this yeast form caused significant depression symptoms when I took it, whereas the yeast-free selenomethionine had no such side effects."

      Delete
  2. i think there are strong connections between selenium and the virulence of coxsackie.

    ReplyDelete
  3. Indeed, there are studies showing that CBV3 cardiomyelitis develops in areas with low Se. I thing many of us with CFS and glutathione issues waste Se because we can't recycle our glutathione.

    Thanks to you both for the references.:)

    ReplyDelete
  4. Have you tried oil pulling? I do know that it makes a huge difference in my energy level and my ability to enjoy life. I used virgin coconut oil. If you havent tried and please do so and be consistent with the practice. Should be done on an empty stomach. Google oil pulling to learn more about it.

    ReplyDelete
  5. i have had the coxackie virus since i was 8. it has been very diffucult. i am unable to work for long periods at a time. my advise, be very very very easy on yourself.

    ReplyDelete
  6. I used to do intense exercise 6 days a week. I am 19 years old and was infected with coxsackie b, 2 months ago, since, I have never been the same, I have done no exercise in the 2 months I sleep up to 11 hours sometimes and still have incredible fatigue, heachaches, ear pain, burning eyes and a hot flushed feeling. I hate my life as it is, what can I do do recover? Is there a chance that I will be normal again?

    ReplyDelete
  7. Give Jim Humble's MMS 1 and 2 a try. It is claimed to help and costs only pennies. His book " The Master Mineral Solution..." is certainly worth a read.

    ReplyDelete
  8. Don't take MMS unless you feel like drinking bleach.

    If you're battling with an enterovirus (coxsackie, echovirus) you need to look into Equilibrant and the work of Dr. John Chia.

    Also, not all viruses stay in the body forever.

    ReplyDelete
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Please add your comments here. If you have a question specific to your own condition, please e-mail me directly at drjanisbell@gmail.com I cannot give medical advice. If you want to suggest a product or therapy you think I should try, please let me know if you have used it, what you used it for, and how it helped you.