Sunday, December 18, 2011
Thursday, December 8, 2011
Friday, November 25, 2011
Of course those with extreme reactivity have a hard time living in society. Many of those I know who've made the best recoveries from CFS live in trailers, which gives them the freedom to move quickly to a place with cleaner air. If a neighbor sprays pesticides or builds a wood fire and you start reacting, you can't move your home. You can only close the windows and turn on the HEPA filter.
So as much as I'd like to have an [immobile] home in which to live, we decided to look for a mobile one.
Tuesday, November 15, 2011
Thursday, November 10, 2011
You "felt the lethargy and fatigue of" your "WORST CFS", so you took a swim, did some yoga, and were still tired? Can you see what's wrong with the picture Janis? Seriously. Talk about stressing or overstressing your overstressed, overtaxed adrenals.
I still don't know what you're running from. I hope you'll address this in your next post.
Saturday, October 29, 2011
|Sunset my last night at City of Rocks, NM|
|View from Burro Creek Campground|
Monday, October 24, 2011
- Reduces apoptosis of glial cells undergoing oxidative stress. Apoptosis is another way of saying that brain cells which have been damaged by free radicals commit suicide (a normal process to make way for new, healthy cells). Yet when there is more death than replacement, cognitive function deteriorates. It’s been said that we don’t notice cognitive deficiencies until we’ve lost about 70% of our brain cells. Yikes! Good to reduce this depletion of our brains by restoring optimal levels of VIP. If the cells don’t commit suicide, they can be repaired and restored to optimal health with reduction in toxins and inflammation and increase in nutrients.
- Raises VEGF, a molecule which helps us build new blood vessels. When too high, VEGF can support the growth of cancer. Too low means less repair of damaged vessels, especially those tiny capillaries which feed every cell in our body. Hence degeneration as tissues which are deprived of the blood bath bringing oxygen and nutrients hold onto the toxins that reduce optimal function.
- Restores circadian rhythm, the daily rhythm of hormones like cortisol, an important adrenal hormone which serves as a buffer against stress and inflammation. Cortisol is highest in the early morning, drops to about half by noon, and then slowly declines in the evening until we are desirous of sleep. Good to reverse an inverted or flat rhythm; the former keeps us up late at night, the latter leaves us in perpetual lethargy. Disturbed adrenal circadian rhythms have been found in CFS-ME, as documented by data at Sabre Sciences, Inc, a lab which offers salivary testing of the circadian rhythm. The majority of indexed studies on adrenal issues in this illness looked a total serum cortisol, finding no pattern other than disturbed regulation of the hypothalamic-pituitary-adrenal axis, while salivary hormone testing measures free cortisol inside the cells. If cAMP is low, cortisol transfer into the cells will suffer. Consequently, when I tested an 8 am serum cortisol and did an 8 am saliva sample at the same time, we found a very high normal serum level and a below normal salivary level. My adrenals were working fine, but my cortisol was all bound by globulins as it couldn’t be transported into the cells which needed it. No wonder I couldn’t tolerate taking Cortef (a cortisol replacement).
- Regulates response to olfactory stimuli in the suprachiastic nucleus, e.g. to smells and chemicals that we breath. Right now, those of us with MCS are hyper-sensitive and get the kind of response to 1/10000th of a scent or odorless chemical that normals get to amounts 10,000 times greater than normal. (Got these figures from Martin Pall, whose theory of MCS involves upregulation of OH and ONOO with NMDA receptor hyper-response.)
- Regulates dendritic cells, immune cells which present antigens to other immune cells so that these antigens can be eliminated. Dendritic cells are found everywhere the body is in contact with the external environment: on the skin and in the inner lining of the nose, lungs, stomach and intestines.
- Regulates Th17 function in autoimmunity, a type of T cell made my interleukin 17 which is found in excessive amounts in MS, psoriasis, rheumatoid arthritis, and other autoimmune disease. They serve an important function at the mucosal barrier by producing cytokines which stimulate these cells to produce chemicals to fight candida, staph, and other microbes. Without Th17 cells, there are more opportunistic infections. I’ll personally be glad to get this working again, as I have had psoriasis ever since I relapsed in 1994, candida from before I got sick, and a tendency to pick up everything that comes along.
- Enhances IL-10, an important anti-inflammatory cytokine which plays a role in the gut-based immune system.
- Modulates innate immunity. This is the part of the immune system that we are born with, our first line of defense against invading pathogens. It is the part that goes wacky in CIRS, and presumably also in CFS.