The normal, recommended starting dose is 4 sprays daily in alternate nostrils for three to six months, then a maintenance dose of two sprays a day. I did two sprays the first day since it arrived late, increased to three the second day, four the third day. I felt quite relaxed and mellow. I slept a lot more. But I noticed that it felt like I ate too much when I had a normal meal.
By the fifth day, I was having major fatigue issues, too tired to do anything until late afternoon. I figured that with the added relaxation effect of the VIP, I was noticing the exhausted state of my adrenals. I decided to try an adrenal glandular my old doctor had given me which, in the past, made me too hyper to sleep. Unwilling to take a big risk, I bit off a 3rd of the tablet and noticed: NOTHING.
After three days of feeling too exhausted to sit up, having almost no appetite, feeling that I could not digest my food, experiencing air hunger, sleeping 9 hours and needing to nap during the day, I decided to stop the VIP. My 'trial' lasted 6 and 1/2 days.
I did some research on the effects of this neuropeptide. It has many effects on the body as do all neurotransmitters, which function somewhat like hormones (in that many tissues, organs, and body systems are affected) Here are some of the things it does:
- regulates neural excitability (hence, I felt like I'd taken a quadruple dose of Xanax)
- involved in learning and memory, especially in brain regions of amygdala, hippocampus, cortex, and hypothalamus (for a list of specific effects, http://www.biomedcentral.com/1471-2202/9/63)
- essential for function of circadian rhythms
- inhibits oxidative stress in the lungs (http://www.ncbi.nlm.nih.gov/pubmed/2474178)
- vasodilation and bronchodilation (http://www.ncbi.nlm.nih.gov/pubmed/15162259)
- increases cardiac contractibility and dilates blood vessels
- induces smooth muscle relaxation in the digestive system especially esophagus, stomach and gallbladder (suggests it should be helpful with GERD)
- reduces gastric acid secretion stimulated by gastrin
- in the intestine, supports secretion of water and electrolytes to produce pancreatic juice and bile, and pancreatic bicarbonate, leading to increased motility